التفاصيل البيبلوغرافية
| العنوان: |
Peripheral Coagulation Parameters and Prostate Cancer Association: A Retrospective Study and Mendelian Randomization. |
| المؤلفون: |
Liu, Feifan, Song, Yufeng, Wu, Fei, Wang, Jianyu, Wang, Delin, Zhao, Zhenlin, Wu, Haihu, Lyu, Jiaju, Ning, Hao |
| المصدر: |
Clinical Medicine Insights: Oncology; 7/26/2024, p1-7, 7p |
| مستخلص: |
Background: The limitations of prostate-specific antigen (PSA) in diagnosing prostate cancer (PCa) necessitate the exploration of novel biomarkers. Recent studies suggest a potential link between coagulation markers, particularly fibrinogen and D-dimer, and PCa. Methods: A retrospective single-center analysis on 466 biopsy-undergone patients was conducted, categorized into PCa and benign prostatic hyperplasia (BPH) groups. Baseline and coagulation parameter levels were analyzed. Utilizing a Mendelian randomization (MR) approach, we investigated the causative relationship between D-dimer and PCa risk. Results: Individuals with PCa, compared with those with BPH, exhibited significantly higher D-dimer levels (P <.001), total PSA (P <.001), and PSA density (P <.001). Fibrinogen levels did not exhibit significant differences (P =.505). The MR analysis suggested a probable causal link between elevated D-dimer levels and an increased risk of PCa (odds ratio: 1.81, 95% confidence interval: 1.48-2.21, P = 7.4 × 10−9). Conclusions: This research highlights D-dimer as a potential biomarker for diagnosing PCa, supported by clinical and MR analyses. The study paves the way for future large-scale, multi-center research to corroborate these findings and further explore the relationship between coagulation markers and PCa mechanisms. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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