التفاصيل البيبلوغرافية
| العنوان: |
Risk Factors Associated with Intensive Care Admission in Children with Severe Acute Respiratory Syndrome Coronavirus 2-Related Multisystem Inflammatory Syndrome (MIS-C) in Latin America: A Multicenter Observational Study of the REKAMLATINA Network. |
| المؤلفون: |
Fernández-Sarmiento, Jaime, Acevedo, Lorena, Niño-Serna, Laura Fernanda, Boza, Raquel, García-Silva, Jimena, Yock-Corrales, Adriana, Yamazaki-Nakashimada, Marco A, Faugier-Fuentes, Enrique, del Águila, Olguita, Camacho-Moreno, German, Estripeaut, Dora, Gutiérrez, Iván F, Luciani, Kathia, Espada, Graciela, Álvarez-Olmos, Martha I, Pérez-Camacho, Paola, Duarte-Passos, Saulo, Cervi, Maria C, Cantillano, Edwin M, Llamas-Guillén, Beatriz A |
| المصدر: |
Journal of Intensive Care Medicine; Aug2024, Vol. 39 Issue 8, p785-793, 9p |
| مصطلحات موضوعية: |
CRITICAL care medicine, SARS disease, MULTISYSTEM inflammatory syndrome, MULTIVARIATE analysis |
| مصطلحات جغرافية: |
LATIN America |
| مستخلص: |
Background: Multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 varies widely in its presentation and severity, with low mortality in high-income countries. In this study in 16 Latin American countries, we sought to characterize patients with MIS-C in the pediatric intensive care unit (PICU) compared with those hospitalized on the general wards and analyze the factors associated with severity, outcomes, and treatment received. Study Design: An observational ambispective cohort study was conducted including children 1 month to 18 years old in 84 hospitals from the REKAMLATINA network from January 2020 to June 2022. Results: A total of 1239 children with MIS-C were included. The median age was 6.5 years (IQR 2.5-10.1). Eighty-four percent (1043/1239) were previously healthy. Forty-eight percent (590/1239) were admitted to the PICU. These patients had more myocardial dysfunction (20% vs 4%; P < 0.01) with no difference in the frequency of coronary abnormalities (P = 0.77) when compared to general ward subjects. Of the children in the PICU, 83.4% (494/589) required vasoactive drugs, and 43.4% (256/589) invasive mechanical ventilation, due to respiratory failure and pneumonia (57% vs 32%; P = 0.01). On multivariate analysis, the factors associated with the need for PICU transfer were age over 6 years (aOR 1.76 95% CI 1.25-2.49), shock (aOR 7.06 95% CI 5.14-9.80), seizures (aOR 2.44 95% CI 1.14-5.36), thrombocytopenia (aOR 2.43 95% CI 1.77-3.34), elevated C-reactive protein (aOR 1.89 95% CI 1.29-2.79), and chest x-ray abnormalities (aOR 2.29 95% CI 1.67-3.13). The overall mortality was 4.8%. Conclusions: Children with MIS-C who have the highest risk of being admitted to a PICU in Latin American countries are those over age six, with shock, seizures, a more robust inflammatory response, and chest x-ray abnormalities. The mortality rate is five times greater when compared with high-income countries, despite a high proportion of patients receiving adequate treatment. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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