دورية أكاديمية
Rab10-CAV1 mediated intraluminal vesicle transport to migrasomes.
| العنوان: | Rab10-CAV1 mediated intraluminal vesicle transport to migrasomes. |
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| المؤلفون: | Yong Li, Yiling Wen, Ying Li, Xinyi Tan, Shuaixin Gao, Peiyao Fan, Wenmin Tian, Wong, Catherine C. L., Yang Chen |
| المصدر: | Proceedings of the National Academy of Sciences of the United States of America; 7/23/2024, Vol. 121 Issue 30, p1-11, 11p |
| مستخلص: | Migrasomes, vesicular organelles generated on the retraction fibers of migrating cells, play a crucial role in migracytosis, mediating intercellular communication. The cargoes determine the functional specificity of migrasomes. Migrasomes harbor numerous intraluminal vesicles, a pivotal component of their cargoes. The mechanism underlying the transportation of these intraluminal vesicles to the migrasomes remains enigmatic. In this study, we identified that Rab10 and Caveolin-1 (CAV1) mark the intraluminal vesicles in migrasomes. Transport of Rab10-CAV1 vesicles to migrasomes required the motor protein Myosin Va and adaptor proteins RILPL2. Notably, the phosphorylation of Rab10 by the kinase LRRK2 regulated this process. Moreover, CSF-1 can be transported to migrasomes through this mechanism, subsequently fostering monocyte--macrophage differentiation in skin wound healing, which served as a proof of the physiological importance of this transporting mechanism. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: | Complementary Index |
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