التفاصيل البيبلوغرافية
| العنوان: |
Significance of PD-L1 and Tumor Microenvironment in Laryngeal Squamous Cell Cancer. |
| المؤلفون: |
Tudor, Filip, Marijić, Blažen, Babarović, Emina, Hadžisejdić, Ita |
| المصدر: |
Cancers; Aug2024, Vol. 16 Issue 15, p2645, 20p |
| مصطلحات موضوعية: |
HEAD & neck cancer treatment, SQUAMOUS cell carcinoma, RESEARCH funding, PROGRAMMED death-ligand 1, CELL physiology, HEAD & neck cancer, RETROSPECTIVE studies, GENE expression, IMMUNOHISTOCHEMISTRY, ODDS ratio, DISEASE relapse |
| مستخلص: |
Simple Summary: Advanced stage laryngeal squamous cell cancer (LSCC) continues to have poor prognosis, with 5-year survival from 50 to 60% and poor functional outcome. PD-L1 and tumor microenvironment (CD4, CD8, CD68 and CD163) expression were investigated in LSCC using immunohistochemistry. PD-L1 expression showed statistically significant positive correlation with all examined tumor microenvironment cells. Higher CD68 and CD163 expression represented significantly worse prognosticators for clinical outcome in patients with LSCC. To find out which LSCC patients will gain from immunomodulation therapies, it is important to understand the relationship between PD-L1 expression, immune cell distribution and prognosis in LSCC patients. Background: Despite the considerable advancement in the field of medicine over recent decades, laryngeal cancer continues to be a challenge. The field of immune oncology has generated promising immunomodulation therapies and opened up new ways of treatment. Methods: Our retrospective study included 102 patients diagnosed with laryngeal squamous cell cancer (LSCC). Immunohistochemistry was used to evaluate the expression of PD-L1 and tumor microenvironment cells (CD4, CD8, CD68 and CD163). Results: PD-L1 expression showed statistically significant positive correlations with all examined tumor microenvironment cells. Patients with high CD68 and CD163 expression intratumorally (p = 0.0005 and p = 0.006, respectively) had statistically significant shorter disease-specific survival. Moreover, a statistically shorter time to recurrence was found in patients with high CD68 intratumoral and CD8 overall counts (p = 0.049 and p = 0.019, respectively). Also, high CD8 overall (>23%) and CD68 intratumoral (>2.7%) expression were statistically significant predictors of recurrence (p = 0.028, OR = 3.11 and p = 0.019, OR = 3.13, respectively). Conclusions: Higher CD68 and CD163 expression represented significantly worse prognosticators for clinical outcomes in patients with LSCC. In order to determine which LSCC patients will benefit from anti-PD-1/PD-L1 inhibitors, it is crucial to elucidate the relationship between PD-L1 expression, immune cell distribution and prognosis in LSCC patients. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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