التفاصيل البيبلوغرافية
| العنوان: |
Stereodivergent Construction of 1,5/1,7‐Nonadjacent Tetrasubstituted Stereocenters Enabled by Pd/Cu‐Cocatalyzed Asymmetric Heck Cascade Reaction. |
| المؤلفون: |
Li, Panpan, Liu, Zijiao, Huo, Xiaohong, Zhang, Wanbin |
| المصدر: |
Angewandte Chemie International Edition; 8/26/2024, Vol. 63 Issue 35, p1-8, 8p |
| مصطلحات موضوعية: |
HECK reaction, METAL catalysts, OXINDOLES, FUNCTIONAL groups, ENANTIOMERS, ALLYLIC alkylation, STEREOISOMERS |
| مستخلص: |
The construction of chiral motifs containing nonadjacent stereocenters in an enantio‐ and diastereoselective manner has long been a challenging task in synthetic chemistry, especially with respect to their stereodivergent synthesis. Herein, we describe a protocol that enables the enantio‐ and diastereoselective construction of 1,5/1,7‐nonadjacent tetrasubstituted stereocenters through a Pd/Cu‐cocatalyzed Heck cascade reaction. Notably, a C=C bond relay strategy involving the shift of the π‐allyl palladium intermediate was successfully applied in the asymmetric construction of 1,7‐nonadjacent stereocenters. The current method allows for the efficient preparation of chiral molecules bearing two privileged scaffolds, oxindoles and non‐natural α‐amino acids, with good functional group tolerance. The full complement of the four stereoisomers of products bearing 1,5/1,7‐nonadjacent stereocenters could be readily accessed by a simple combination of two chiral metal catalysts with different enantiomers. [ABSTRACT FROM AUTHOR] |
|
Copyright of Angewandte Chemie International Edition is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder