التفاصيل البيبلوغرافية
| العنوان: |
Diagnostic features of autoimmune hepatitis in SARS-CoV-2-vaccinated vs. unvaccinated individuals. |
| المؤلفون: |
AKIFUMI KUWANO, SHIGEHIRO NAGASAWA, YUTA KOGA, KOSUKE TANAKA, MASAYOSHI YADA, AKIHIDE MASUMOTO, KENTA MOTOMURA |
| المصدر: |
Experimental & Therapeutic Medicine; Sep2024, Vol. 28 Issue 3, p1-7, 7p |
| مصطلحات موضوعية: |
CHRONIC active hepatitis, SARS-CoV-2, AUTOIMMUNE hepatitis, COVID-19, VACCINATION status, COVID-19 pandemic |
| مستخلص: |
The global coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has affected millions of lives, leading to significant morbidity and mortality. With >772 million cases and nearly seven million deaths reported worldwide to date, the development of vaccines has been a critical step in mitigating the impact of COVID-19. However, concerns have arisen regarding the potential for SARS-CoV-2 mRNA vaccination to trigger autoimmune diseases, including autoimmune hepatitis (AIH). The present single-center, retrospective study aimed to compare the clinical and pathological features of AIH in patients with or without a history of SARS-CoV-2 mRNA vaccination. A total of 72 patients with AIH were examined. Among them, 10 had received the SARS-CoV-2 mRNA vaccination prior to AIH onset. These patients exhibited more pronounced CD4+ T cell infiltration into the liver tissue compared with those who were unvaccinated. No significant differences in the levels of other liver enzymes, autoimmune antibodies, or CD8+ T cell infiltration were observed between the groups. Moreover, the AIH patients with a history of SARS-CoV-2 mRNA vaccination had more extensive CD4+ T cell infiltration in their liver tissues than the unvaccinated patients. These findings suggested that the immune response to SARS-CoV-2 mRNA vaccination may influence the pathogenesis of AIH, highlighting the need for further research into the relationship between SARS-CoV-2 mRNA vaccination and autoimmune liver diseases. Such studies will also help clarify the distinction between vaccine-induced liver injury and traditional AIH. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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