التفاصيل البيبلوغرافية
| العنوان: |
Rapid brain lymphoma diagnostics through nanopore sequencing of cytology-negative cerebrospinal fluid. |
| المؤلفون: |
Hench, J., Hultschig, C., Bratic Hench, I., Sadasivan, H., Yaldizli, Ö, Hutter, G., Dirnhofer, S., Tzankov, A., Frank, S. |
| المصدر: |
Acta Neuropathologica; 9/3/2024, Vol. 148 Issue 1, p1-4, 4p |
| مصطلحات موضوعية: |
DIFFUSE large B-cell lymphomas, CELL-free DNA, SOLID state drives, DNA methylation, DNA copy number variations, CEREBROSPINAL fluid examination, RHINORRHEA |
| مستخلص: |
This article discusses a new method for diagnosing brain lymphoma using nanopore sequencing of cerebrospinal fluid (CSF). The study demonstrates the clinical application of this method in two cases of CNS lymphoma. The researchers adapted their fast-track unsupervised machine learning approach for cases with a differential diagnosis of lymphoma and other malignant brain tumors. The results showed that nanopore sequencing-derived methylation patterns can be used for next-day diagnosis and treatment initiation. This point-of-care protocol has the potential to significantly reduce neurological impairment through timely and non-invasive testing. [Extracted from the article] |
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| قاعدة البيانات: |
Complementary Index |
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