التفاصيل البيبلوغرافية
| العنوان: |
COMPARATIVE PROSPECTIVE STUDY OF CARTRIDGE-BASED NUCLEIC ACID AMPLIFICATION TEST (CBNAAT) WITH FINE NEEDLE ASPIRATION CYTOLOGY AND HISTOPATHOLOGY EXAMINATION ON CASES OF SUSPECTED PALPABLE TUBERCULAR LYMPHADENOPATHY. |
| المؤلفون: |
Raj, Hans, Parihar, Ummed Singh, Agarwal, Kalpana, Kuldeep, Rajveer, Rawal, Pramod, Lakhotiya, Priyanka |
| المصدر: |
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research); 2024, Vol. 15 Issue 8, p292-298, 7p |
| مصطلحات موضوعية: |
NUCLEIC acid amplification techniques, NEEDLE biopsy, TUBERCULIN test, LYMPH nodes, LYMPHADENITIS, APPETITE loss |
| مستخلص: |
Introduction: In developing countries the detection of TBLN is a major challenge. The clinical parameters for the diagnosis of TB in lymph nodes are not specific for some cases and the absence of lymphadenitis does not rule out TB involvement. Aim: Diagnosis of tubercular lymph node by CBNAAT on lymph node tissue taken by excisional biopsy in case of suspected palpable tubercular lymphadenopathy and comparison of CBNAAT with FNAC and histopathology examination. Methods: This was a Prospective observational study, conducted on 50 suspected and confirmed case of tubercular lymphadenopathy, attending outpatient department or admitted during January 2021–December 2022 in the department of surgery JLN Hospital Ajmer. Results: Mean age of study population was 29 ± 15.64 yearrs. The most common presenting complaint was swelling (100%) followed by loss of weight (50%) and loss of appetite (40%). Mean ESR was 43 ± 24.01 per hr. 54% of the patients had positive mantoux test for TB. On histopathology, 60% cases were diagnosed as Tubercular. 2 (4%) male and 3 (6%) female had rifampicin resistance on CBNAAT. CBNAAT the true positive were 23 whereas true negative were 20. FNAC the true positive were 27 whereas true negative were 18. CBNAAT, PPV (66.66), NPV(100), Sensitivity= 100%, and Specificity= 74.07%. FNAC, Positive Predictive Value = 90%, Negative Predictive Value = 90%, Sensitivity= 93.1%, and Specificity= 85.71%. Conclusion: With high sensitivity and average specificity of CBNAAT and FNAC they are a good tool for diagnosis in combination with other testing modality like culture and histopathology examination. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
