التفاصيل البيبلوغرافية
| العنوان: |
Differences in the Renal Accumulation of Radiogallium-Labeled (Glu) 14 Peptides Containing Different Optical Isomers of Glutamic Acid. |
| المؤلفون: |
Ogawa, Kazuma, Nishizawa, Kota, Mishiro, Kenji, Munekane, Masayuki, Fuchigami, Takeshi, Echigo, Hiroaki, Wakabayashi, Hiroshi, Kinuya, Seigo |
| المصدر: |
Molecules; Sep2024, Vol. 29 Issue 17, p3993, 9p |
| مصطلحات موضوعية: |
OPTICAL isomers, GLUTAMIC acid, AMINO acids, BONE metastasis, STEREOISOMERS |
| مستخلص: |
Acidic amino acid peptides have a high affinity for bone. Previously, we demonstrated that radiogallium complex-conjugated oligo-acidic amino acids possess promising properties as bone-seeking radiopharmaceuticals. Here, to elucidate the effect of stereoisomers of Glu in Glu-containing peptides [(Glu)14] on their accumulation in the kidney, the biodistributions of [67Ga]Ga-N,N′-bis-[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine-N,N′-diacetic acid-conjugated (l-Glu)14 ([67Ga]Ga-HBED-CC-(l-Glu)14), [67Ga]Ga-HBED-CC-(d-Glu)14, [67Ga]Ga-HBED-CC-(dl-Glu)14, and [67Ga]Ga-HBED-CC-(d-Glu-l-Glu)7 were compared. Although the accumulation of these compounds in the bone was comparable, their kidney accumulation and retention were strikingly different, with [67Ga]Ga-HBED-CC-(d-Glu-l-Glu)7 exhibiting the lowest level of kidney accumulation among these compounds. Repeated d- and l-peptides may be a useful method for reducing renal accumulation in some cases. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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