التفاصيل البيبلوغرافية
| العنوان: |
Zafirlukast ameliorates lipopolysaccharide and bleomycin-induced lung inflammation in mice. |
| المؤلفون: |
Xue, Tongtong, Zhang, Qianyi, Zhang, Tiantian, Meng, Lingxin, Liu, Jing, Chai, Dan, Liu, Yuming, Yang, Zhongyi, Jiao, Ran, Cui, Yunyao, Gao, Jingjing, Li, Xiaohe, Xu, Aiguo, Zhou, Honggang |
| المصدر: |
BMC Pulmonary Medicine; 9/16/2024, Vol. 24 Issue 1, p1-15, 15p |
| مصطلحات موضوعية: |
RESPIRATORY insufficiency, PNEUMONIA, EPITHELIAL cells, LEUKOTRIENE antagonists, LUNG injuries, PULMONARY fibrosis |
| مستخلص: |
Acute lung injury (ALI) is the result of damage to the capillary endothelia and the alveolar epithelial cell caused by various direct and indirect factors, leading to significant pulmonary interstitial and alveolar edema and acute hypoxic respiratory insufficiency. A subset of ALI cases progresses to irreversible pulmonary fibrosis, a condition with fatal implications. Zafirlukast is a leukotriene receptor antagonist licensed for asthma prevention and long-term treatment. This study demonstrated a significant improvement in lung tissue pathology and a reduction in inflammatory cell infiltration in models of lipopolysaccharide (LPS)-induced ALI and bleomycin (BLM)-induced lung inflammation following zafirlukast administration, both in vivo and in vitro. Moreover, zafirlukast was found to suppress the inflammatory response of alveolar epithelial cells in vitro and lung inflammation in vivo by reducing the activation of the TLR4/NF-κB/NLRP3 inflammasome pathway. In conclusion, zafirlukast relieved lung injury and the infiltration of inflammatory cells in the lung by regulating the TLR4/NF-κB/NLRP3 pathway. [ABSTRACT FROM AUTHOR] |
|
Copyright of BMC Pulmonary Medicine is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Find this article in full text from Springer Verlag. 
Full Text Finder