التفاصيل البيبلوغرافية
| العنوان: |
Liposomal formulation of a gold(III) metalloantibiotic: a promising strategy against antimicrobial resistance. |
| المؤلفون: |
Llamedo, Alejandro, Rodríguez, Pablo, Gabasa, Yaiza, Soengas, Raquel G., Rodríguez-Solla, Humberto, Elorriaga, David, García-Alonso, Francisco J., Soto, Sara M. |
| المصدر: |
Dalton Transactions: An International Journal of Inorganic Chemistry; 9/28/2024, Vol. 53 Issue 36, p15205-15214, 10p |
| مصطلحات موضوعية: |
DRUG resistance in microorganisms, CELL survival, CYTOCHROMES, LIPOSOMES, GOLD |
| مستخلص: |
A novel lipoformulation was developed by encapsulating cationic (S^C)-cyclometallated gold(III) complex [Au(dppta)(N2Py-PZ-dtc)]+ (AuPyPZ) in liposomes. The liposomal form of compound AuPyPZ has a bactericidal action similar to that of the free drug without any appreciable effect on the viability of mammalian cells. Furthermore, the nanoformulation reduces metalloantibiotic-induced inhibition of hERG and the inhibition of cytochromes, significantly decreasing the potential liabilities of the metallodrug. The obtained metalloantibiotic liposomal formulation shows high stability and suitable properties for drug delivery, representing an effective strategy to fight against drug-resistant bacteria. [ABSTRACT FROM AUTHOR] |
|
Copyright of Dalton Transactions: An International Journal of Inorganic Chemistry is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
