دورية أكاديمية
Substrate properties of dinucleoside 5',5?-oligophosphates in the reactions catalyzed by HIV reverse transcriptase, E. coli DNA polymerase I, and E. coli RNA polymerase.
| العنوان: | Substrate properties of dinucleoside 5',5?-oligophosphates in the reactions catalyzed by HIV reverse transcriptase, E. coli DNA polymerase I, and E. coli RNA polymerase. |
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| المؤلفون: | A. Yu. Skoblov, V. V. Sosunov, L. S. Victorova, Yu. S. Skoblov, M. K. Kukhanova |
| المصدر: | Russian Journal of Bioorganic Chemistry; Jan2005, Vol. 31 Issue 1, p48-57, 10p |
| مصطلحات موضوعية: | ESCHERICHIA coli, ZINC enzymes, DINUCLEOSIDE polyphosphates, ESCHERICHIA |
| مستخلص: | Abstract Dinucleoside 5',5?-oligophosphates d(Np4N'), dTp3rA, dTp4rA, and dTp5rA were synthesized and evaluated as substrates for HIV reverse transcriptase, the Klenow fragment of E. coli DNA polymerase I, and E. coli RNA polymerase. A model of the HIV reverse transcriptase interaction with the dinucleoside oligophosphates was proposed and experimentally confirmed. The kinetic constants of some of the synthesized compounds for the HIV reverse transcriptase were determined. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: | Complementary Index |
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