التفاصيل البيبلوغرافية
| العنوان: |
Distinct Domains of Human CDC5 Direct Its Nuclear Import and Association with the Spliceosome. |
| المؤلفون: |
Liansen Liu, Remo Gräub, Myint Hlaing, Conrad L. Epting, Christoph W. Turck, Xiao-Qin Xu, Leanne Zhang, Harold S. Bernstein |
| المصدر: |
Cell Biochemistry & Biophysics; 10/01/2003, Vol. 39 Issue 2, p119-132, 14p |
| مستخلص: |
Genetic studies have shown that CDC5 proteins are essential for G2 progression and mitotic entry. CDC5 homologs in yeast and mammals are essential for pre-messenger ribonucleic acid (mRNA) processing. Other gene products also have been shown to play roles in both pre-mRNA splicing and cell cycle regulation, prompting the description of several models to explain the mechanism(s) linking these two processes. In this study, we demonstrate that the amino-terminus of human CDC5 directs nuclear import independent of consensus nuclear localization signals or phosphorylation, and that the carboxyl-terminus of human CDC5 preferentially associates with spliceosomal complexes in proximity of RNA transcription during interphase. hCDC5 colocalizes with Sm proteins in a cell cycle- and domain-dependent manner, and several proteins in the human CDC5-associated complex are identified that suggest potential roles for the complex in coupling pre-mRNA splicing to transcriptional activation and protein translation. These results indicate that human CDC5 may function in pre-mRNA processing and cell cycle progression through more than one mechanism. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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