التفاصيل البيبلوغرافية
| العنوان: |
The switch mechanism and the bipolar/unipolar dichotomy. |
| المؤلفون: |
Carney, M. W. P., Chary, T. K. N., Bottiglieri, T., Reynolds, E. H., Carney, M W, Chary, T K |
| المصدر: |
British Journal of Psychiatry; Jan89, Vol. 154, p48-51, 4p, 3 Charts |
| مصطلحات موضوعية: |
METHIONINE, CLINICAL trials, PLACEBOS, BIPOLAR disorder, HYPOMANIA, CEREBROSPINAL fluid, ADENOSYLMETHIONINE, COMPARATIVE studies, EMOTIONS, INTRAVENOUS injections, RESEARCH methodology, MEDICAL cooperation, ORAL drug administration, RESEARCH, EVALUATION research, RANDOMIZED controlled trials, THERAPEUTICS, PSYCHOLOGY |
| مستخلص: |
During open trials of intravenous and oral S-adenosyl methionine (SAM) and a placebo-controlled trial of intravenous SAM in 29 patients, 25 patients had SAM and four had placebo (27 courses of SAM, two of the patients receiving two trials a piece). Nine of 11 bipolar patients (all SAM-treated) switched into elevated mood state (hypomania, mania and euphoria) and two did not respond. Six endogenous unipolar patients improved and five did not. No non-endogenous patient or placebo patient responded for more than 14 days. No unipolar patient switched into elated mood. In eleven (38%) trials and nine (33%) patients there was a switch from depression to elation. Biochemical data from the cerebrospinal fluid of eight patients suggested that the role of the dopaminergic system should be further explored. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
