Uropathogenic Escherichia coli (UPEC) strains may carry virulence properties of diarrhoeagenic E. coli.

التفاصيل البيبلوغرافية
العنوان:	Uropathogenic Escherichia coli (UPEC) strains may carry virulence properties of diarrhoeagenic E. coli.
المؤلفون:	Abe, Cecilia M., Salvador, Fábia A., Falsetti, Ivan N., Vieira, Mônica A.M., Blanco, Jorge, Blanco, Jesús E., Blanco, Miguel, Machado, Antônia M.O., Elias, Waldir P., Hernandes, Rodrigo T., Gomes, Tânia A. T.
المصدر:	FEMS Immunology & Medical Microbiology; Apr2008, Vol. 52 Issue 3, p397-406, 10p, 5 Charts
مصطلحات موضوعية:	ESCHERICHIA coli, MICROBIAL virulence, DIARRHEA, INFECTION, GENES, URINARY tract infections, COMMUNICABLE diseases, MEDICAL microbiology, URINARY organ diseases
مستخلص:	To analyze whether Escherichia coli strains that cause urinary tract infections (UPEC) share virulence characteristics with the diarrheagenic E. coli (DEC) pathotypes and to recognize their genetic diversity, 225 UPEC strains were examined for the presence of various properties of DEC and UPEC (type of interaction with HeLa cells, serogroups and presence of 30 virulence genes). No correlation between adherence patterns and serogroups was observed. Forty-five serogroups were found, but 64% of the strains belonged to one of the 12 serogroups (O1, O2, O4, O6, O7, O14, O15, O18, O21, O25, O75, and O175) and carried UPEC virulence genes ( pap, hly, aer, sfa, cnf). The DEC genes found were: aap, aatA, aggC, agg3C, aggR, astA, eae, ehly, iha, irp2, lpfA O113, pet, pic, pilS, and shf. Sixteen strains presented aggregative adherence and/or the aatA sequence, which are characteristics of enteroaggregative E. coli (EAEC), one of the DEC pathotypes. In summary, certain UPEC strains may carry DEC virulence properties, mostly associated to the EAEC pathotype. This finding raises the possibility that at least some faecal EAEC strains might represent potential uropathogens. Alternatively, certain UPEC strains may have acquired EAEC properties, becoming a potential cause of diarrhoea. [ABSTRACT FROM AUTHOR]
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قاعدة البيانات:	Complementary Index

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