التفاصيل البيبلوغرافية
| العنوان: |
Shifting to first-line regimen after previous failure of irinotecan and oxaliplatin containing chemotherapies in unresectable metastatic colorectal cancer : a retrospective study of case analysis. |
| المؤلفون: |
Chao-Wen Hsu, Tai-Ming King, Chieh-Hsin Lin, Hsin-Tai Wang, Wen-Chieh Ou, Jui-Ho Wang |
| المصدر: |
International Journal of Colorectal Disease; Apr2009, Vol. 24 Issue 4, p377-383, 7p, 1 Black and White Photograph, 4 Charts |
| مصطلحات موضوعية: |
COLON cancer treatment, CANCER patients, DRUG therapy, OXALIPLATIN, METASTASIS, CONTROL groups |
| مستخلص: |
Conventional use of FOLFIRI–FOLFOX or the reverse sequence is the optional regimen in metastatic unresectable colorectal cancer (CRC). We present our experience in chemotherapy (C/T) shifting to first-line regimen after previous failure of irinotecan and oxaliplatin containing regimens. A total of 48 patients with metastatic unresectable CRC were examined retrospectively. All the patients had both failure of a first-line C/T and a second-line C/T. Of these patients, 13 patients received C/T shifting to first-line regimen. Data were collected retrospectively. Rate of disease control of 38.4% was achieved (five in 13 patients). In the positive disease control group, metastatic sites were all extra-hepatic (five patients). In the negative disease control group, hepatic metastatic rate was 62.5% (five in eight patients, P = 0.044). Even after previous failure of irinotecan and oxaliplatin containing C/T, we observe positive disease control response and survival benefit in selected patients with C/T shifting to the first-line regimen especially in extra-hepatic metastasis. The preliminary results are proposed to gain insight into the need for further investigations and large-scale studies. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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