التفاصيل البيبلوغرافية
| العنوان: |
Simple chromosome exchanges are not linear with dose. |
| المؤلفون: |
Edwards, A. A., Hone, P. A., Moquet, J. E., Lloyd, D. C. |
| المصدر: |
International Journal of Radiation Biology; Sep99, Vol. 75 Issue 9, p1113-1117, 5p, 1 Black and White Photograph, 4 Charts, 1 Graph |
| مصطلحات موضوعية: |
CHROMOSOME analysis, DOSE-response relationship (Radiation) |
| مستخلص: |
Purpose: To check whether simple chromosome exchanges are linearly related to radiation dose. Materials and methods: Go-irradiated lymphocytes were cultured to produce metaphase preparations. Chromosomes 1 and 2 were painted different colours and the remaining chromosomes counterstained. Cells containing a colour junction involving both chromosomes 1 and 2 were scored fully, so that simple and complex rearrangements were distinguished. Results: At doses of 2Gy and below very few complex rearrangements were seen. About 90% of exchanges were simple. At these doses the linear component of the dose-effect curve accounts on average for only ~30% of the observed yield. Conclusions: There is a square-law dose component to the yield of simple exchanges in addition to the linear term. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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