دورية أكاديمية
Erythropoietin elevates V̇O2, max but not voluntary wheel running in mice.
العنوان: | Erythropoietin elevates V̇ |
---|---|
المؤلفون: | Kolb, E. M., Kelly, S. A., Middleton, K. M., Sermsakdi, L. S., Chappell, M. A., Garland Jr., T. |
المصدر: | Journal of Experimental Biology; Feb2010, Vol. 213 Issue 3, p510-519, 10p, 4 Charts, 2 Graphs |
مصطلحات موضوعية: | PHYSIOLOGICAL transport of oxygen, AEROBIC capacity, ERYTHROPOIETIN, ERYTHROCYTE biotechnology, LABORATORY mice, OXYHEMOGLOBIN, SYMMORPHOSIS |
مستخلص: | Voluntary activity is a complex trait, comprising both behavioral (motivation, reward) and anatomical/physiological (ability) elements. In the present study, oxygen transport was investigated as a possible limitation to further increases in running by four replicate lines of mice that have been selectively bred for high voluntary wheel running and have reached an apparent selection limit. To increase oxygen transport capacity, erythrocyte density was elevated by the administration of an erythropoietin (EPO) analogue. Mice were given two EPO injections, two days apart, at one of two dose levels (100 or 300μg kg-1). Hemoglobin concentration ([Hb]), maximal aerobic capacity during forced treadmill exercise (V̇ |
Copyright of Journal of Experimental Biology is the property of Company of Biologists Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
قاعدة البيانات: | Complementary Index |
كن أول من يترك تعليقا!