التفاصيل البيبلوغرافية
| العنوان: |
Cardiac manifestations in mid-gut carcinoid disease. |
| المؤلفون: |
JACOBSEN, M. B., NITTER-HAUGE, S., BRYDE, P. E., HANSSEN, L. E. |
| المصدر: |
European Heart Journal; Feb1995, Vol. 16 Issue 2, p263-268, 6p |
| مستخلص: |
The extent of heart disease and its relationship to the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA), was studied with M-mode, 2D and Doppler echocardiography in 42 consecutive patients, 30 females and 12 males, median age 63 (range 23–75) years with histologically verified mid-gut tumour, liver metastases and 24-h urinary 5-HIAA excretion above 47 μmol. 24h. All patients had normal left ventricular ejection fractions, median 65% (interquartile range (IQR) 54–74%). Moderate to severe tricuspid regurgitation (TR) was diagnosed in 22 patients (59%); mitral or aortic regurgitation was found in nine (24%) and six (16%) patients, respectively. The mitral flow peak early (E) on late (A) velocity ratio was significantly decreased compared to age-matched normal subjects. The group of patients with 5- excretion exceeding 1000μmol. 24h contained significantly more patients with severe TR than those with a lower excretion. The decrease in the El A ratio may indicate reduced left ventricular compliance, possibly secondary to fibrous changes similar to those seen intra-abdominally and in the right side of the heart. As serotonin is degraded in the lung circulation, other mediators such as tachykinins and cytokines (PDGF) may be involved. [ABSTRACT FROM PUBLISHER] |
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| قاعدة البيانات: |
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