التفاصيل البيبلوغرافية
| العنوان: |
Facile fabrication of magnetic metal–organic framework nanocomposites for potential targeted drug deliveryElectronic supplementary information (ESI) available: Fe3O4contents, and drug loading capacities of Fe3O4/Cu3(BTC)2nanocomposites, TGA, NIM release kinetics. See DOI: 10.1039/c0jm01770a/ |
| المؤلفون: |
Fei Ke, Yu-Peng Yuan, Ling-Guang Qiu, Yu-Hua Shen, An-Jian Xie, Jun-Fa Zhu, Xing-You Tian, Li-De Zhang |
| المصدر: |
Journal of Materials Chemistry; Mar2011, Vol. 21 Issue 11, p3843-3848, 6p |
| مستخلص: |
In this paper, we describe a facile, efficient, and environmentally friendly fabrication of a novel type of magnetic porous metal–organic-framework (MOF)-based nanocomposites that can be potentially used for targeted drug delivery. The magnetic MOF nanocomposites were fabricated by incorporation of Fe3O4nanorods with nanocrystals of Cu3(BTC)2(HKUST-1), a three dimensional (3D) MOF with a 3D channel system. The as-synthesized materials exhibited both magnetic characteristics and high porosity, making them excellent candidates for targeted drug delivery systems. An anti-cancer drug acting as a selective cyclooxygenase-2 (COX-2) inhibitor for pancreatic cancer treatment, Nimesulide, was laden into pores of the nanocomposites. These MOF-based magnetic nanocomposites could adsorb up to 0.2 g of Nimesulide per gram of composite, and it took as long as 11 days to complete the drug release in physiological saline at 37 °C. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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