التفاصيل البيبلوغرافية
| العنوان: |
'Active' T-cell Rosettes and total T-rosettes in patients with melanoma following intratumoral inoculation of BCG: A clue to the mechanism of action of bacillus calmette-guérin? |
| المؤلفون: |
Wybran, J., Spitler, L., Lieberman, R., Fudenberg, H. |
| المصدر: |
Cancer Immunology, Immunotherapy; Jun1976, Vol. 1 Issue 3, p153-156, 4p |
| مستخلص: |
Six patients with cutaneous metastases of malignant melanoma were treated with bacillus Calmette-Guérin (BCG). Rosette formation by sheep erythrocytes surrounding thymus-derived lymphocytes was studied by two methods ('active' and total rosette-forming cells) before and after therapy. Four patients showed good clinical response with regression of some or all skin nodules, and two did not respond. All four responders showed an increase in 'active' rosette-forming cells; two also had increases in total rosette-forming cells. One nonresponder had an increase in 'active' rosette-forming cells. It is proposed that BCG activates both nonspecific and specific thymus-derived cell populations. Traffic of thymus-derived cells may also occur after administration of BCG. [ABSTRACT FROM AUTHOR] |
|
Copyright of Cancer Immunology, Immunotherapy is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Find this article in full text from Springer Verlag. 
Full Text Finder