التفاصيل البيبلوغرافية
| العنوان: |
Estimation of plasma apolipoprotein B concentration using routinely measured lipid biochemical tests in apparently healthy Asian adults. |
| المؤلفون: |
Dong-Sik Cho, Sookyoung Woo, Seonwoo Kim, Byrne, Christopher D., Joon-Hyuk Kong, Ki-Chul Sung |
| المصدر: |
Cardiovascular Diabetology; 2012, Vol. 11 Issue 1, p55-60, 6p, 4 Charts, 1 Graph |
| مصطلحات موضوعية: |
APOLIPOPROTEIN B, CARDIOVASCULAR diseases, LOW density lipoproteins, BIOCHEMISTRY, ISOPENTENOIDS |
| مستخلص: |
Background: Increased low-density lipoprotein cholesterol (LDL) concentration is associated with increased risk of coronary heart disease (CHD) but a substantial risk of cardiovascular disease often remains after LDL concentrations have been treated to target. Apolipoprotein B (apo B) is the major apolipoprotein contained within atherogenic lipoproteins such as LDL, and apo B is a more reliable indicator of cardiovascular risk than LDL concentration. Aim and methods: Our aim was to develop a formula for calculating apo B using lipid biochemistry measurements that are commonly available in clinical practice. We examined the clinical and laboratory data from 73,047 Koreans who underwent a medical health check that included apolipoprotein B concentration. The study sample was randomly divided into a training set for prediction model building and a validation set of equal size. Multivariable linear regression analysis was used to develop a prediction model equation for estimating apo B and to validate the developed model. Results: The best results for estimating apo B were derived from an equation utilising LDL and triglyceride (TG) concentrations [ApoB = ?33.12 + 0.675*LDL + 11.95*ln(tg)]. This equation predicted the apo B result with a concordance correlation coefficient (CCC and 95%CIs) = 0.936 (0.935,0.937)). Conclusion: Our equation for predicting apo B concentrations from routine analytical lipid biochemistry provides a simple method for obtaining precise information about an important cardiovascular risk marker. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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