التفاصيل البيبلوغرافية
| العنوان: |
Prenatal Diagnosis of Cystic Hygroma related to a Deletion of 16q24.1 with Haplo insufficiency of FOXF1 and FOXC2 Genes. |
| المؤلفون: |
Garabedian, Matthew J., Wallerstein, Donna, Medina, Nubia, Byrne, James, Wallerstein, Robert J. |
| المصدر: |
Case Reports in Genetics; 2012, p1-4, 4p |
| مصطلحات موضوعية: |
PRENATAL diagnosis, LYMPHATIC abnormalities, DELETION mutation, HAPLOIDY, COMPARATIVE genomic hybridization, CARDIOPULMONARY system, ETIOLOGY of diseases, HUMAN abnormalities |
| مستخلص: |
We report the prenatal diagnosis of cystic hygroma that was subsequently identified to have haploinsufficiency of the FOXF1 and FOXC2 genes via array comparative genomic hybridization (aCGH). Deletion of these genes has previously neither been associated with cystic hygroma nor prenatally diagnosed. The FOX gene cluster is involved in cardiopulmonary development. This case expands the phenotypic spectrum of abnormalities of the FOXF1 and FOXC2 genes, as it seems within the spectrum of function that disruption of the FOX gene cluster would lead to include abnormalities of prenatal onset. Identification of this association would not be possible with conventional karyotype or targeted aCGH. This case highlights the power of whole genomic aCGH to further delineate the etiology of birth defects. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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