دورية أكاديمية
Rectal ropivacaine is absorbed proportionally to the dose, with low intraindividual variability.
العنوان: | Rectal ropivacaine is absorbed proportionally to the dose, with low intraindividual variability. |
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المؤلفون: | Arlander, Eva, Sjövall, Jan, Sörstad, Jörgen, Norsten-Höög, Carina, Gustafsson, Lars L. |
المصدر: | British Journal of Clinical Pharmacology; Jan2003, Vol. 55 Issue 1, p14-22, 9p |
مصطلحات موضوعية: | ULCERATIVE colitis, THERAPEUTICS |
مستخلص: | Aims This study investigated the absorption characteristics and the tolerability of rectally administered ropivacaine, a local anaesthetic, intended as a new local therapy for ulcerative colitis. Methods Thirty-two healthy volunteers participated in a randomized, placebo-controlled study. In study phase 1 (n = 16, double-blind, crossover) single rectal doses of ropivacaine corresponding to 50, 100 and 200 mg base were given as 20-ml gel enemas. Eight of these subjects also received an i.v. infusion corresponding to 20 mg (2 H |
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قاعدة البيانات: | Complementary Index |
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