التفاصيل البيبلوغرافية
| العنوان: |
Salivary Ig A response to probiotic bacteria and mutans streptococci after the use of chewing gum containing Lactobacillus reuteri. |
| المؤلفون: |
Ericson, Dan, Hamberg, Kristina, Bratthall, Gunilla, Sinkiewicz-Enggren, Gabriela, Ljunggren, Lennart |
| المصدر: |
Pathogens & Disease; Aug2013, Vol. 68 Issue 3, p82-87, 6p, 1 Chart, 6 Graphs |
| مصطلحات موضوعية: |
IMMUNOGLOBULIN A, STREPTOCOCCUS, MICROBIAL mutation, CHEWING gum, IMMUNE response, LACTOBACILLUS reuteri, PROBIOTICS, SALIVA microbiology, INGESTION, BACTERIAL antibodies |
| مستخلص: |
We investigated whether ingestion of probiotic bacteria could influence salivary Ig A levels, specific anti-mutans streptococci Ig A levels and specific antibodies towards the ingested probiotic bacterium. The study was a randomised, double-blind, placebo-controlled trial, where the test group ( n = 11) received twice daily chewing of gum containing Lactobacillus reuteri (2 × 108 CFU per dose) and the control group ( n = 12) received placebo. Resting saliva was collected before and after 12 weeks of treatment and 4 weeks after end of treatment. Total salivary Ig A concentrations were measured by ELISA. Specific Ig A reactivity was determined using a whole-cell ELISA. Results were expressed as % Ig A per protein in saliva. The level of total Ig A% per protein increased significantly between pretreatment levels (13.5%) and follow-up treatment levels (14.4%) within the test group only ( P < 0.05). No changes were seen in the control group during the trial. The level of probiotic-reactive antibodies decreased significantly between pre- and post-treatment samples (from 12.2% to 9.0%, P < 0.05) in the test group. Similarly, the level of specific mutans streptococci antibodies decreased significantly between pre- and post-treatment samples ( P < 0.05) in the test group only (for Streptococcus mutans from 20.1% to 15.0%; for Streptococcus sobrinus from 7.4% to 5.3%). Ingestion of probiotic bacteria might influence the adaptive immune response of the host. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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