دورية أكاديمية
A Chiral Benzyl Group as a Chiral Auxiliary and Protecting Group for the Synthesis of Optically Active 1,2-Diols and (+)-Frontalin.
| العنوان: | A Chiral Benzyl Group as a Chiral Auxiliary and Protecting Group for the Synthesis of Optically Active 1,2-Diols and (+)-Frontalin. |
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| المؤلفون: | Tae Hyun Kim, Young-Kyo Kim, Zhnhua Yang, Jung Wha Jung, Lak Shin Jeong, Hee-Doo Kim |
| المصدر: | Synlett; 2014, Vol. 25 Issue 2, p251-254, 4p |
| مصطلحات موضوعية: | GLYCOL synthesis, NUCLEOPHILIC addition (Chemistry), GRIGNARD reagents, KETONES, STEREOSELECTIVE reactions |
| مستخلص: | Chelation-controlled asymmetric nucleophilic addition of a Grignard reagent to chiral α-benzyloxy ketones gives the corresponding alcohols with high diastereoselectivities (up to 96% de) by 1,4-asymmetric induction. A chiral benzyl group is used as a chiral auxiliary as well as a protecting group for the synthesis of optically active 1,2-diols and (+)-frontalin. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: | Complementary Index |
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