دورية أكاديمية
Gene Therapy for Rheumatoid Arthritis: Theoretical Considerations.
| العنوان: | Gene Therapy for Rheumatoid Arthritis: Theoretical Considerations. |
|---|---|
| المؤلفون: | Mageed, R.A., Chernajovsky, Y., Podhajcer, O.L., Annenkov, A., Baker, D., Herman, C., Triantaphyllopoulos, K., Gould, D., Dreja, H., Moyes, S.P., Croxford, J.L. |
| المصدر: | Drugs & Aging; 1998, Vol. 12 Issue 1, p29-41, 13p |
| مصطلحات موضوعية: | RHEUMATOID arthritis, IMMUNOGLOBULINS, CYTOKINES, DISEASE vectors, GENE therapy |
| مستخلص: | Current understanding of the pathogenesis of rheumatoid arthritis has provided evidence that therapeutic benefit can be achieved by using antagonists targeted to the inflammatory cytokines involved, mainly tumour necrosis factor-α and interleukin-1. Gene delivery of antagonists, which can inhibit the production or action of these cytokines and other mediators, has been achieved in experimental animal models. This new method of delivery can produce therapeutic effects at lower concentrations and in a local environment, overcoming the adverse effects that often accompany protein therapy. However, several technological and biological restraints preclude the immediate adaptation of this method to human treatment. Based on the experimental evidence, possible target therapeutic genes, cell types and vector systems that could be used are discussed in this article. [ABSTRACT FROM AUTHOR] |
| Copyright of Drugs & Aging is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| قاعدة البيانات: | Complementary Index |
Find this article in full text from Springer Verlag. 
Full Text Finder كن أول من يترك تعليقا!