دورية أكاديمية
Effects of HIV-1 Nef on Retrograde Transport from the Plasma Membrane to the Endoplasmic Reticulum.
العنوان: | Effects of HIV-1 Nef on Retrograde Transport from the Plasma Membrane to the Endoplasmic Reticulum. |
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المؤلفون: | Johannes, Ludger, Pezo, Valérie, Mallard, Frédéric, Tenza, Danièle, Wiltz, Aimée, Saint-Pol, Agnès, Helft, Julie, Antony, Claude, Benaroch, Philippe |
المصدر: | Traffic; May2003, Vol. 4 Issue 5, p323-332, 10p |
مصطلحات موضوعية: | PROTEINS, BIOLOGICAL transport |
مستخلص: | HIV-1 Nef protein down-regulates several important immunoreceptors through interactions with components of the intracellular sorting machinery. Nef expression is also known to induce modifications of the endocytic pathway. Here, we analyzed the effects of Nef on retrograde transport, from the plasma membrane to the endoplasmic reticulum using Shiga toxin B-subunit (STxB). Nef expression inhibited access of STxB to the endoplasmic reticulum, but did not modify the surface expression level of STxB receptor, Gb |
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قاعدة البيانات: | Complementary Index |
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