التفاصيل البيبلوغرافية
| العنوان: |
A Lectin from S patholobus parviflorus Inhibits A spergillus flavus α-Amylase: Enzyme Kinetics and Thermodynamic Studies. |
| المؤلفون: |
Tintu, Ignatius, Abhilash, Joseph, Dileep, Kalarickal V., Augustine, Anu, Haridas, Madathilkovilakath, Sadasivan, Chittalakkottu |
| المصدر: |
Chemical Biology & Drug Design; Jul2014, Vol. 84 Issue 1, p116-122, 7p |
| مصطلحات موضوعية: |
ASPERGILLUS flavus, LECTINS, ANTIFUNGAL agents, METABOLITES, AFLATOXINS, ENZYME kinetics, SPATHOLOBUS parviflorus |
| مستخلص: |
Aspergillus flavus is a commonly found fungal pathogen which produces structurally related and highly toxic secondary metabolites, aflatoxins. It has been proposed that α-amylase inhibitors may limit the ability of the fungus to produce aflatoxins. Hence, this enzyme is a potent target for the development of antifungal agents. In this study, it was found that Spatholobus parviflorus seed lectin ( SPL) can inhibit the growth of A. flavus with a MIC value of 1.5 mg/mL. The enzyme kinetics, molecular modeling and isothermal titration calorimetric studies suggest that SPL can inhibit α-amylase with Ki value of 0.0042 m m. Hence, it is suggested that the antifungal activity of SPL might be partly due to its ability to inhibit the enzyme α-amylase. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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