التفاصيل البيبلوغرافية
| العنوان: |
Identification of the 1B vaccine strain of Chlamydia abortus in aborted placentas during the investigation of toxaemic and systemic disease in sheep. |
| المؤلفون: |
Sargison, ND, Truyers, IGR, Howie, FE, Thomson, JR, Cox, AL, Livingstone, M, Longbottom, D |
| المصدر: |
New Zealand Veterinary Journal; Sep2015, Vol. 63 Issue 5, p284-287, 4p |
| مصطلحات موضوعية: |
CHLAMYDIA infections in animals, SHEEP diseases, SHEEP, ABORTION, EWES, BACTERIAL diseases in animals |
| مستخلص: |
CASE HISTORY: One hundred and forty Cheviot and 100 Suffolk cross Mule primiparous 1–2-year-old ewes, from a flock of about 700 ewes, were vaccinated with an attenuated live 1B strainChlamydia abortusvaccine about 4 weeks before ram introduction (September 2011). Between 08 March and 01 April 2012, 50 2-year-old ewes aborted and 29 of these died, despite antimicrobial and anti-inflammatory treatment and supportive care. PATHOLOGICAL FINDINGS: Seven fetuses and three placentae from five 2-year-old ewes were submitted for pathological investigation. The aborted fetuses showed stages of autolysis ranging from being moderately fresh to putrefaction. Unusual, large multifocal regions of thickened membranes, with a dull red granular surface and moderate amounts of grey-white surface exudate were seen on each of the placentae. Intracellular, magenta-staining, acid fast inclusions were identified in Ziehl Neelsen-stained placental smears. Immunohistochemistry forChlamydia-specific lipopolysaccharide showed extensive positive labelling of the placental epithelia. LABORATORY FINDINGS: Molecular analyses of the aborted placentae demonstrated the presence of the 1B vaccine-type strain ofC. abortusand absence of any wild-type field strain. The vaccine strain bacterial load of the placental tissue samples was consistent with there being an association between vaccination and abortion. DIAGNOSIS: Initial laboratory investigations resulted in a diagnosis of chlamydial abortion. Further investigations led to the identification of the 1B vaccine strain ofC. abortusin material from all three of the submitted aborted placentae. CLINICAL RELEVANCE: Timely knowledge and understanding of any potential problems caused by vaccination againstC. abortusare prerequisites for sustainable control of chlamydial abortion. This report describes the investigation of an atypical abortion storm in sheep, and describes the identification of the 1B vaccine strain ofC. abortusin products of abortion. The significance of this novel putative association between the vaccine strain ofC. abortusand severe clinical disease is unknown. Aspects of the approach that is described are relevant to the investigation of all outbreaks of ovine abortion, irrespective of the diagnosis. Awareness of the changing role ofC. abortusas a major global cause of abortion ought to reinforce the importance of monitoring of adequate biosecurity in those countries which are currently free from chlamydial abortion. [ABSTRACT FROM PUBLISHER] |
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