دورية أكاديمية
Effectiveness and Toxicity of Intrastromal Amphotericin B Injection in Treating Fusarium solani keratitis: Animal Experimental Study.
| العنوان: | Effectiveness and Toxicity of Intrastromal Amphotericin B Injection in Treating Fusarium solani keratitis: Animal Experimental Study. |
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| المؤلفون: | Che Mahiran Che Daud, Neoh Yee Ling, Md Salzihan Md Salleh, Siti Suraiya Mohd Nor, Noramazlan Ramli, Mohtar Ibrahim, Ahmad Tajudin, Liza-Sharmini |
| المصدر: | International Medical Journal; Jun2016, Vol. 23 Issue 3, p262-266, 5p |
| مستخلص: | Objective: To compare the effectiveness and safety between intrastromal injection of Amphotericin B 0.15% (1.5 mg/ml) and 0.0005% (5 g/ml) in treating Fusarium solani keratitis in rabbits. Design: This is a randomized controlled trial. Material and methods: Animal experimental randomized controlled trial was conducted involving eighteen New Zealand white rabbits. After successful inoculation of Fusarium solani on the debrided right corneal of the rabbits, the rabbits were equally randomized into 3 groups; Group A received topical 0.15% amphotericin B every hourly for 12 hours daily (control), Group B received intrastromal amphotericin B injection 0.15% and Group C were treated with intrastromal injection 0.0005% of amphotericin B. The intrastromal injection was given at day 3, 6, 9 and 11. The size of the epithelial defect, the depth of the ulcer, stromal infiltration, hypopyon and the presence of satellite lesion were graded at day 3, 6, 9, 11 and 14. All the eyes were enucleated on day 14 for histopathological analysis to assess the fungal load, depth of the ulcer, intensity of inflammation and presence of granulation tissue. Results: There was statistical significant difference of the total grading of clinical observation between group C and B (p < 0.001) especially in the size of epithelial defect (p = 0.02) and satellite lesion (p = 0.02). There was also absence of fungal load, the depth of ulcer limited to anterior two third with moderate inflammatory responses and mild granulation tissue in group C. Conclusions: Intrastromal injection of amphotericin B 0.0005% (5 µg/ml) is potentially beneficial in treating Fusarium solani keratitis, especially in refractory cases at a reduced cost and shorter hospital stay. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: | Supplemental Index |
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