دورية أكاديمية
Bioactive constituents of the stem bark of Bersama abyssinica Fresen subsp. abyssinica Verdc. (Melianthaceae).
| العنوان: | Bioactive constituents of the stem bark of Bersama abyssinica Fresen subsp. abyssinica Verdc. (Melianthaceae). |
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| المؤلفون: | Tsafack, Vanessa Charnele, Dongmo, Appolinaire Kene, Nono, Raymond Ngansop, Tabekoueng, Georges Bellier, Neumann, Beate, Stammler, Hans-Georg, Bankeu, Jean Jules Kezetas, Kouam, Siméon Fogué, Nkeng-Efouet-Alango, Pépin, Lenta, Bruno Ndjakou, Sewald, Norbert, Chouna, Jean Rodolphe |
| المصدر: | Phytochemistry Letters; Feb2024, Vol. 59, p53-58, 6p |
| مستخلص: | A new xanthone glycoside (1) and a new bufadienolide (2) named bersamaxanthoside and bersamabufadienolide, respectively, together with seventeen known compounds (3 – 19) were isolated from the stem bark of Bersama abyssinica Fresen subsp. abyssinica Verdc. Their structures were elucidated based on their spectroscopic data. The extract, fractions and compounds were assessed for their cytotoxicity on the cervix carcinoma cell line KB-3–1. The MeOH extract and the EtOAc and n-BuOH soluble fractions exhibited weak activity with IC 50 values of 0.085, 0.084 and 0.075 mg/mL, respectively. The other tested samples were inactive. In addition, some of the isolates were tested for their DPPH radical scavenging activity and only compounds 1 , 11–13 , 16 , and 17 displayed antioxidant properties with IC 50 values ranging from 2.9 to 38.1 µg/mL. [Display omitted] • A new xanthone glycoside and a new bufadienolide from Bersama abyssinica stem bark. • A lignan and a benzoquinone are firstly reported form the genus Bersama. • The cytotoxicity and DPPH radical scavenging activities of extracts and isolates. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: | Supplemental Index |
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