| مستخلص: |
PURPOSE: To investigate the clinical effect of nutritional supplementation through percutaneous endoscopic gastrostomy on head and neck cancer patients undergoing radiotherapy. METHODS: One hundred and three head and neck cancer patients who received radiotherapy with food intake limitation and need of nutrition supplementation were randomly divided into two groups: PEG group of 47 cases and nasal feeding group of 56 cases. The patients were supplemented with same intensity food through percutaneous endoscopic gastrostomy and nasal intubation. Patients' mood, appetite, life quality, tolerance and compliance were observed during treatment. Infection situation was recorded, infection rate and average Defined Daily Dose (DDD) number during whole course were calculated. Nutrition index, including body weight, serum album, transferrin, were also tested before and after radiotherapy respectively. The data was analyzed with SPSS 11.0 software package. RESULTS: In clinical observation, patients' mood, appetite and life quality decreased un-obviously after radiotherapy, but tolerance and compliance increased obviously, and social activities were not affected in PEG group. But in nasal intubation group, the status was not optimistic, patients' mood, appetite and life quality were depressed, their tolerance and compliance were bad, social activities were reduced. The infection rate in PEG group was 19.1%, which was significantly less than 33.9% of nasal intubation group (P=0.0292). Accordingly, DDDs in PEG group was 1.5, smaller than 4.3 of nasal intubation group. In nutrition index, body weight and serum album decreased sharply from (63.6±4.2) kg and (34.0±4.5) g/L before treatment to (60.7±2.5) kg and (31.4±3.8) g/L after treatment in PEG group, but transferrin increased from (27.6±3.9) |xmol/L to (28.4±1.3) |xmol/L, although no significant difference was noted. In the same way, body weight, serum album and transferrin decreased from (65.3±5.6) kg, (33.7±3.1) g/L and (28.2±2.1) |xmol/L before treatment to (58.4±3.3) kg, (29.6±4.3) g/L and (26.2±2.3) |xmol/L after treatment in nasal intubation group obviously (P<0.05). Although nutrition index decreased after radiotherapy, those loss in PEG group was much less than in nasal intubation group, respectively. CONCLUSIONS: Supplementation through percutaneous endoscopic gastrostomy in head and neck cancer patients who undergo radiotherapy does not increase infection rate, and can improve patients' tolerance and compliance, accordingly improve their nutrition status and enhance their life quality. PEG can be used in head and neck cancer patients' nutrition who receive radiotherapy. [ABSTRACT FROM AUTHOR] |
