دورية
An in Vivo Model for HIV Resistance Development
| العنوان: | An in Vivo Model for HIV Resistance Development |
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| المؤلفون: | Zuber, Bartek, Böttiger, Disa, Benthin, Reinhold, ten Haaft, Peter, Heeney, Jonathan, Wahren, Britta, Öberg, Bo |
| المصدر: | AIDS Research and Human Retroviruses; May 1, 2001, Vol. 17 Issue: 7 p631-635, 5p |
| مستخلص: | Treatment of human immunodeficiency virus (HIV-1) with drugs targeted to the reverse transcriptase (RT) rapidly selects for drug-resistant virus. It is essential to develop a suitable animal model that allows the study of the emergence and reversal of drug resistance. A monkey model was previously developed on the basis of a hybrid virus (RT-SHIV) of simian immunodeficiency virus (SIV) with its RT exchanged for HIV-1 RT. In the present study cynomolgus monkeys infected with RT-SHIV were treated with varying doses of the non-nucleoside RT inhibitor nevirapine. The drug was administered for 2-3 weeks, in agreement with clinical experience of resistance development during nevirapine monotherapy. This resulted in the selection of mutants with Y181C and K103N changes in RT, which correspond to the HIV-1 mutations in nevirapine-resistant HIV-1 patients. The mutants coexisted at varying levels with wild-type virus and fluctuations in the proportion of mutants could be closely monitored. Low-dose treatment was not more efficient in induction of mutations than a virus-inhibiting dose. Structured therapy interruptions could be performed. The monkey RT-SHIV infection offers an in vivo model to determine effects of therapies on resistance development. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 08892229 19318405 |
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| DOI: | 10.1089/088922201300119734 |