دورية
Immune Interference in Mycobacterium tuberculosisIntracellular Iron Acquisition through Siderocalin Recognition of Carboxymycobactins
| العنوان: | Immune Interference in Mycobacterium tuberculosisIntracellular Iron Acquisition through Siderocalin Recognition of Carboxymycobactins |
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| المؤلفون: | Hoette, Trisha M., Clifton, Matthew C., Zawadzka, Anna M., Holmes, Meg A., Strong, Roland K., Raymond, Kenneth N. |
| المصدر: | ACS Chemical Biology; December 2011, Vol. 6 Issue: 12 p1327-1331, 5p |
| مستخلص: | The innate immune system antibacterial protein Siderocalin (Scn) binds ferric carboxymycobactin (CMB) and also several catecholate siderophores. Although the recognition of catecholates by Scn has been thoroughly investigated, the binding interactions of Scn with the full spectrum of CMB isoforms have not been studied. Here we show that Scn uses different binding modes for the limited subset of bound CMB isoforms, resulting in a range of binding affinities that are much weaker than other siderophore targets of Scn. Understanding the binding interaction between Scn and CMBs provides clues for the influence of Scn on mycobacterial iron acquisition. |
| قاعدة البيانات: | Supplemental Index |
Find this issue from the American Chemical Society | تدمد: | 15548929 15548937 |
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| DOI: | 10.1021/cb200331g |