Synthesis and biological evaluation of new tetrahydronaphthalene derivatives as thromboxane receptor antagonists

التفاصيل البيبلوغرافية
العنوان: Synthesis and biological evaluation of new tetrahydronaphthalene derivatives as thromboxane receptor antagonists
المؤلفون: Cimetière, Bernard, Dubuffet, Thierry, Muller, Olivier, Descombes, Jean-Jacques, Simonet, Serge, Laubie, Michel, Verbeuren, Tony J., Lavielle, Gilbert
المصدر: Bioorganic & Medicinal Chemistry Letters; June 1998, Vol. 8 Issue: 11 p1375-1380, 6p
مستخلص: New polysubstituted tetrahydronaphthalene derivatives were prepared as thromboxane receptor (TP-receptor) antagonists. Within this series of compounds S 18886has been identified as an orally active, highly potent antagonist with a very long duration of action in different species.
قاعدة البيانات: Supplemental Index
الوصف
تدمد:0960894X
14643405
DOI:10.1016/S0960-894X(98)00220-0