دورية
Posttransfusion Purpura: Conversion of PLA1-Negative Platelets to the PLA1-Positive Phenotype by Stored Plasma is not due to the Presence of Soluble PLA1Antigen
| العنوان: | Posttransfusion Purpura: Conversion of PLA1-Negative Platelets to the PLA1-Positive Phenotype by Stored Plasma is not due to the Presence of Soluble PLA1Antigen |
|---|---|
| المؤلفون: | Ehmann, W. C., Dancis, A., Ferziger, R., Karpatkin, S. |
| المصدر: | Experimental Biology and Medicine; November 1990, Vol. 195 Issue: 2 p192-196, 5p |
| مستخلص: | Three previous articles have reported a PLA1antigen in the plasma of stored blood which is capable of binding to PLA1-negative platelets in the presence of divalent cations, rendering them PLA1positive. Such a mechanism could explain the enigma of posttransfusion purpura (PTP), i.e., severe thrombocytopenia in a healthy subject with PLA1-negative platelets secondary to the infusion of blood containing PLA1-positive platelets. We find that the PLA1antigen of stored blood is due to the presence of platelet fragments which can be removed by centrifugation and that divalent cation-chelating agents play no role in the apparent binding of these fragments to platelets. The apparent conversion of PLA1-negative platelets to the PLA1-positive phenotype by incubation with stored plasma from a PLA1-positive subject is due to the cosedimentation of platelet fragments with the platelets. No soluble PLA1antigen was found in the plasma of five patients with acute posttransfusion purpura. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 15353702 15353699 |
|---|---|
| DOI: | 10.3181/00379727-195-43133 |