دورية
Increased Plasma Levels of Atrial Natriuretic Factor, Renin Activity, and Leukotriene C4in Chronic Obstructive Pulmonary Disease
| العنوان: | Increased Plasma Levels of Atrial Natriuretic Factor, Renin Activity, and Leukotriene C4in Chronic Obstructive Pulmonary Disease |
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| المؤلفون: | Piperno, Daniel, Pacheco, Yves, Hosni, Rachid, Moliere, Patrick, Gharib, Claude, Hagarde, Michel, Perrin-Fayolle, Max |
| المصدر: | Chest; August 1993, Vol. 104 Issue: 2 p454-459, 6p |
| مستخلص: | We studied atrial natriuretic factor (ANF), plasma renin activity (PRA), and plasma levels of leukotrienes (LTs) B4and C4in 23 patients with COPD undergoing right cardiac catheterization for suspected pulmonary hypertension. Hemodynamic measurements together with concomitant ANF levels (both in venous and pulmonary artery blood and right atrial and pulmonary artery plasma levels of LTC4and LTB4, were determined at rest (TO), after 30 min of breathing oxygen (3 L/min) (Tl), and after 30 min recovering and breathing air (T2). Patients with effective exacerbation or definitive evidence of left ventricular disease, hypertension, arrhythmias, or vasodilator or diuretic therapy were excluded. Increased levels of ANF, both in peripheral venous blood (117 ±65 pg/ml) and the pulmonary artery (153±75 pg/ml), were found in patients with COPD, with or without pulmonary hypertension. Levels of LTC4were also significantly increased (366±406 pg/ml) when compared with our control values. No correlations among ANF, LTC4values, functional tests, and hemodynamic measurements were found. Brief increased levels of oxygen did not modify ANF or LTC4plasma levels, either in patients with or without pulmonary hypertension. |
| قاعدة البيانات: | Supplemental Index |
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