دورية
Coronary vasomotion in response to sympathetic stimulation in humans: Importance of the functional integrity of the endothelium
| العنوان: | Coronary vasomotion in response to sympathetic stimulation in humans: Importance of the functional integrity of the endothelium |
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| المؤلفون: | Zeiher, Andreas M., Drexler, Helmut, Wollschlaeger, Helmut, Saurbier, Bernward, Just, Hanjoerg |
| المصدر: | Journal of the American College of Cardiology; November 1989, Vol. 14 Issue: 5 p1181-1190, 10p |
| مستخلص: | The coronary vasomotor response to the cold pressor test was studied with use of quantitative coronary angiography in 32 patients without evidence of coronary artery disease and 55 patients with such disease; in a subset of 22 patients (9 with normal coronary arteries and 13 with coronary artery disease), the effects of the cold pressor test were compared with the effects of the endothelium-dependent vasodilator acetylcholine with simultaneous intracoronary Doppler flow velocity measurements to assess the influence of endothelial dysfunction. The cold pressor test induced vasodilation of 8.9 ± 5.7% in all 77 analyzed vessel segments of the group with normal arteries (p < 0.01). In contrast, in patients with coronary artery disease, the 52 analyzed stenotic segments were constricted by −12.1 ± 9.5% (p < 0.01), the 57 analyzed vessel segments with luminal irregularities were constricted by −8.9 ± 5.2% (p < 0.01) and 40 (85%) of 47 angiographically normal segments also were constricted by −7.0 ± 4.9% (p < 0.05). |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 07351097 15583597 |
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| DOI: | 10.1016/0735-1097(89)90414-2 |