دورية
Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity
| العنوان: | Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity |
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| المؤلفون: | Usui, Toru, Faulkner, Lee, Farrell, John, French, Neil S., Alfirevic, Ana, Pirmohamed, Munir, Park, B. Kevin, Naisbitt, Dean J. |
| المصدر: | Chemical Research in Toxicology; 20240101, Issue: Preprints |
| مستخلص: | It is unclear whether priming of naïve T cells to drugs is detectable in healthy human donors expressing different human leukocyte antigen (HLA) alleles. Thus, we examined T cell priming with drugs associated with HLA risk alleles and control compounds in 14 HLA-typed donors. Nitroso sulfamethoxazole and piperacillin activated T cells from all donors, whereas responses to carbamazepine and oxypurinol were only seen in donors expressing HLA-B*15:02 and HLA-B*58:01, respectively. Weak flucloxacillin-specific T cell responses were detected in donors expressing HLA-B*57:01 and HLA-B*58:01. These data show that the priming of T cells with certain drugs is skewed toward donors expressing specific HLA alleles. |
| قاعدة البيانات: | Supplemental Index |
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