دورية
Studies on the substituted 3-aminopropan-1-ol motif of lycoctonine class norditerpenoid alkaloids: A novel route to 3-hydroxymethylcyclohex-2-enone
| العنوان: | Studies on the substituted 3-aminopropan-1-ol motif of lycoctonine class norditerpenoid alkaloids: A novel route to 3-hydroxymethylcyclohex-2-enone |
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| المؤلفون: | Doisy, Xavier, Blagbrough, Ian S., Thomas, Noel F., Potter, Barry V.L. |
| المصدر: | Tetrahedron Letters; January 1998, Vol. 39 Issue: 46 p8525-8528, 4p |
| مستخلص: | Pursuing our interest in methyllycaconitine (MLA), we have designed a synthetic route to substituted ring-A of lycoctonine class norditerpenoid alkaloids. A novel synthesis of 3-hydroxymethylcyclohex-2-enone has been achieved starting from cyclohex-2-enone. Key reactions are: 1,2-addition of 1,3-dithiane followed by allylic rearrangement, 1,4-hydrocyanation, Wittig reaction and conversion into the substituted N-ethyl-3-aminopropan-1-ol motif of these neopentyl-like alcohols. |
| قاعدة البيانات: | Supplemental Index |
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