دورية
The presence of LHRH‐like receptors in Dunning R3327H prostate tumors
| العنوان: | The presence of LHRH‐like receptors in Dunning R3327H prostate tumors |
|---|---|
| المؤلفون: | Hierowski, Marion T., Perla, Altamirano, Redding, Tommie W., Schally, Andrew V. |
| المصدر: | FEBS Letters; April 1983, Vol. 154 Issue: 1 p92-96, 5p |
| مستخلص: | Quantitative analyses of LH‐RH‐like membrane receptors were performed in five tumors from the transplantable Dunning R3372H rat prostatic adenocarcinoma. The binding of D‐Trp6‐LH‐RH, an agonist of LH‐RH, was observed in all 5 tumors. The antagonist [Ac‐Dp‐Cl‐Phe1,2,D‐Trp3,D‐Lys6,D‐Ala10]‐LH‐RH was bound to 4 tumors. The apparent equilibrium dissociation constant (Kd) for D‐Trp6‐LH‐RH receptor was from 2.6–3.9 × 10−10M. The apparent equilibrium Bmaxvalues (maximum number of binding sites) were from 17.2–86.0 fmol/mg membrane protein for D‐Trp6‐LH‐RH receptor. The Kdfor the antagonist was from 2.4–2.7 × 10−10M and the Bmaxvalues were from 35.5–66.0 fmol/mg membrane protein. Similar binding studies performed in 6 normal rat prostates showed no binding capacities. |
| قاعدة البيانات: | Supplemental Index |
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