دورية
-Synuclein, pesticides, and Parkinson disease
| العنوان: | -Synuclein, pesticides, and Parkinson disease |
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| المؤلفون: | Brighina, L, Frigerio, R, Schneider, N K., Lesnick, T G., de Andrade, M, Cunningham, J M., Farrer, M J., Lincoln, S J., Checkoway, H, Rocca, W A., Maraganore, D M. |
| المصدر: | Neurology (Ovid); April 2008, Vol. 70 Issue: 16 p1461-1469, 9p |
| مستخلص: | Aggregation and fibrillization of the -synuclein protein (encoded by the SNCAgene) may represent key events in the pathogenesis of Parkinson disease (PD). Variability in the length of a dinucleotide repeat sequence (REP1) within the SNCApromoter confers susceptibility to sporadic PD. Pesticide exposures may also confer susceptibility to PD. Our objective was to test possible joint effects of SNCAREP1 genotypes and pesticide exposures on the risk of PD. |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 00283878 1526632X |
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| DOI: | 10.1212/01.wnl.0000304049.31377.f2 |