دورية
Inhibition of cPLA2and sPLA2Activities in Primary Cultures of Rat Cortical Neurons by Centella asiaticaWater Extract
| العنوان: | Inhibition of cPLA2and sPLA2Activities in Primary Cultures of Rat Cortical Neurons by Centella asiaticaWater Extract |
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| المؤلفون: | Defillipo, Patrícia P., Raposo, André H., Fedoce, Alessandra G., Ferreira, Aline S., Polonini, Hudson C., Gattaz, Wagner F., Raposo, Nádia R. B. |
| المصدر: | Natural Product Communications; July 2012, Vol. 7 Issue: 7 |
| مستخلص: | Leaf extract of Centella asiaticahas been used as an alternative medicine for memory improvement in the Indian Ayurvedic system of medicine for a long time. Although several studies have revealed its effect in ameliorating the cognitive impairment in rat models of Alzheimer's disease, the molecular mechanism of C. asiaticaon neuroprotection still remains unexplained. In this study, we investigated the effects of C. asiaticawater extract on activity of subtypes of phospholipase A2(PLA2) in primary cultures of rat cortical neurons and quantified by HPLC a possible molecule responsible for the activity. The cPLA2and sPLA2activities were inhibited in vitroby asiaticoside present in the water extract of C. asiatica.This extract may be a candidate for the treatment of neurodegenerative processes because of its pharmacological activity in the brain and its low toxicity, as attested by its long popular use as a natural product. |
| قاعدة البيانات: | Supplemental Index |
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