Mycobacterium tuberculosisType VII Secretion System Effectors Differentially Impact the ESCRT Endomembrane Damage Response

التفاصيل البيبلوغرافية
العنوان:	Mycobacterium tuberculosisType VII Secretion System Effectors Differentially Impact the ESCRT Endomembrane Damage Response
المؤلفون:	Mittal, Ekansh, Skowyra, Michael L., Uwase, Grace, Tinaztepe, Emir, Mehra, Alka, Köster, Stefan, Hanson, Phyllis I., Philips, Jennifer A.
المصدر:	mBio; December 2018, Vol. 9 Issue: 6
مستخلص:	Mycobacterium tuberculosiscauses tuberculosis, which kills more people than any other infection. M. tuberculosisgrows in macrophages, cells that specialize in engulfing and degrading microorganisms. Like many intracellular pathogens, in order to cause disease, M. tuberculosisdamages the membrane-bound compartment (phagosome) in which it is enclosed after macrophage uptake. Recent work showed that when chemicals damage this type of intracellular compartment, cells rapidly detect and repair the damage, using machinery called the endosomal sorting complex required for transport (ESCRT). Therefore, we hypothesized that ESCRT might also respond to pathogen-induced damage. At the same time, our previous work showed that the EsxG-EsxH heterodimer of M. tuberculosiscan inhibit ESCRT, raising the possibility that M. tuberculosisimpairs this host response. Here, we show that ESCRT is recruited to damaged M. tuberculosisphagosomes and that EsxG-EsxH undermines ESCRT-mediated endomembrane repair. Thus, our studies demonstrate a battle between host and pathogen over endomembrane integrity.
قاعدة البيانات:	Supplemental Index

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