دورية
Possible specific chromosome change in prolymphocytic leukemia
| العنوان: | Possible specific chromosome change in prolymphocytic leukemia |
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| المؤلفون: | Sadamori, N, Han, T, Minowada, J, Bloom, ML, Henderson, ES, Sandberg, AA |
| المصدر: | Blood; October 1983, Vol. 62 Issue: 4 p729-736, 8p |
| مستخلص: | The chromosomes of unstimulated and stimulated blood lymphocytes from 5 cases with B-cell prolymphocytic leukemia (PLL) were examined following the use of polyclonal B-cell activators (PBA). Banding techniques revealed a common and specific chromosome abnormality to be present in each of the cases, which was due to a translocation between chromosomes 6 and 12 (t(6;12)(q15;p13]. The fact that this specific chromosome change has not been reported in other lymphoproliferative disorders may indicate that PLL is a distinct clinical entity and different from other lymphoproliferative disorders, whether it occurs de novo or complicates chronic lymphocytic leukemia (CLL). |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 00064971 15280020 |
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| DOI: | 10.1182/blood.V62.4.729.729 |