دورية
Deficient of LRRC8Aattenuates hypoxia-induced necrosis in 3T3-L1 cells
| العنوان: | Deficient of LRRC8Aattenuates hypoxia-induced necrosis in 3T3-L1 cells |
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| المؤلفون: | Luo, Funong, Long, Keren, Li, Xiaokai, Mai, Miaomiao, Zhong, Zhining, Li, Side, Li, Penghao, Zhou, Shuling, Zhang, Tinghuan, Long, Xi, Jin, Long, Li, Mingzhou |
| المصدر: | Bioscience, Biotechnology, and Biochemistry; June 2020, Vol. 84 Issue: 6 p1139-1145, 7p |
| مستخلص: | ABSTRACTUnder acute hypoxia, multiple ion channels on the cell membrane are activated, causing cell swelling and eventually necrosis. LRRC8Ais an indispensable protein of the volume-regulated anion channel (VRAC), which participates in swelling and the acceleration of cell necrosis. In this study, we revealed a dynamic change in the expression level of the LRRC8family during hypoxia in 3T3-L1 cells. The disruption of LRRC8Ain 3T3-L1 cells was also associated with a significant anti-necrotic phenotype upon hypoxia accompanied by the reduced expression of necrosis-related genes. In vivo, differential expression of LRRC8family members was also identified between high-altitude pigs and their low-altitude relatives. Taken these findings together, this study demonstrates the involvement of LRRC8Ain hypoxia-induced cell necrosis. |
| قاعدة البيانات: | Supplemental Index |
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