دورية
Spatial localization of SOCE channels and its modulators regulate neuronal physiology and contributes to pathology
| العنوان: | Spatial localization of SOCE channels and its modulators regulate neuronal physiology and contributes to pathology |
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| المؤلفون: | Sun, Yuyang, Nascimento Da Conceicao, Viviane, Ahamad, Naseem, Madesh, Muniswamy, Singh, Brij B |
| المصدر: | Current Opinion in Physiology; October 2020, Vol. 17 Issue: 1 p50-62, 13p |
| مستخلص: | Ca2+function as second messenger and changes in cytosolic Ca2+levels dictate neuronal physiology. Although several Ca2+entry channels are present in neuronal cells, release of Ca2+from intracellular endoplasmic reticulum (ER) stores modulates store-operated Ca2+entry (SOCE) that restore ER Ca2+levels and maintains Ca2+homeostasis in organelles such as: mitochondria, Golgi apparatus, lysosomes and associated vesicles, and nucleus. Members of the Orai and canonical TRPC channels that are gated by ER Ca2+sensor STIM1 induces SOCE in neuronal and associated cells. Similarly, mitochondrial Ca2+uniporter is essential for mitochondrial Ca2+uptake; whereas two-pore Ca2+channels and the mucolipin are essential for lysosomal functions. Interestingly, spatiotemporal compartmentalization of Ca2+in various organelle modulate diverse and opposing functions. Thus, interplay between organelle Ca2+and Ca2+influx provide the spatial resolution that is imperative for executing the precise neuronal responses and alterations in Ca2+signaling leads to neuronal loss. |
| قاعدة البيانات: | Supplemental Index |
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