دورية
Analysis of Single-Nucleotide Polymorphisms in the crt-oand mdr1Genes of Plasmodium vivaxamong Chloroquine-Resistant Isolates from the Brazilian Amazon Region
| العنوان: | Analysis of Single-Nucleotide Polymorphisms in the crt-oand mdr1Genes of Plasmodium vivaxamong Chloroquine-Resistant Isolates from the Brazilian Amazon Region |
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| المؤلفون: | Orjuela-Sánchez, Pamela, de Santana Filho, Franklin Simões, Machado-Lima, Ariane, Chehuan, Yonne Francis, Costa, Mônica Regina Farias, Alecrim, Maria das Graças Costa, del Portillo, Hernando A. |
| المصدر: | Antimicrobial Agents and Chemotherapy; August 2009, Vol. 53 Issue: 8 p3561-3564, 4p |
| مستخلص: | ABSTRACTPlasmodium vivaxparasites with chloroquine resistance (CQR) are already circulating in the Brazilian Amazon. Complete single-nucleotide polymorphism (SNP) analyses of coding and noncoding sequences of the pvmdr1and pvcrt-ogenes revealed no associations with CQR, even if some mutations had not been randomly selected. In addition, striking differences in the topologies and numbers of SNPs in these transporter genes between P. vivaxand P. falciparumreinforce the idea that mechanisms other than mutations may explain this virulent phenotype in P. vivax. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 00664804 10986596 |
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| DOI: | 10.1128/AAC.00004-09 |