دورية
Sharpless Asymmetric Epoxidation: Applications in the Synthesis of Bioactive Natural Products
| العنوان: | Sharpless Asymmetric Epoxidation: Applications in the Synthesis of Bioactive Natural Products |
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| المؤلفون: | Sartori, Suélen K., Miranda, Izabel Luzia, Diaz, Marisa A. N., Diaz-Muñoz, Gaspar |
| المصدر: | Mini-Reviews in Organic Chemistry; August 2021, Vol. 18 Issue: 5 p606-620, 15p |
| مستخلص: | This review discusses an important synthetic tool proposed by K.B. Sharpless in 1980, known as the Sharpless asymmetric epoxidation of allylic alcohols, and examines its use in the total synthesis of representative exponents of biologically active natural products. Focus is given to the synthesis of simple to highly complex secondary metabolites, including lactones, amino acids, diterpenes, and macrolides. The Sharpless approach involves the use of a catalyst, titanium tetra isopropoxide [Ti(OiPr) |
| قاعدة البيانات: | Supplemental Index |
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